CANCER DE MAMA
|
Descriptor Inglés:
|
|
Breast Neoplasms
|
|
Descriptor Español:
|
|
Neoplasias de la Mama
|
|
Descriptor Portugués:
|
|
Neoplasias da Mama
|
|
Sinónimos Español:
|
|
Cáncer de Mama
Cáncer de la Mama Cancer de Seno Cáncer Mamario Neoplasias Mamarias Tumores de la Mama Tumores de Mama Tumor de Seno Tumores de Seno Tumores Mamarios |
|
Categoría:
|
|
|
|
Definición Español:
|
|
|
FILTROS:
Publicacion: 10 años
Especies: humanos
Sexo: femenino
Edad: 19 a mas años
Lenguaje: español.
[Utility of chromosome banding with ALU I enzyme for
identifying methylated areas in breastcancer].
[Article in Spanish]
Rojas-Atencio A, Yamarte L, Urdaneta K, Soto-Alvarez M, Alvarez Nava F, Cañizalez J, Quintero M, Atencio R, González R.
Source
Instituto de Investigaciones Genéticas,
Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
arojasa26@gmail.com
Abstract
Cancer is a group of disorders characterized by uncontrolled cell growth
which is produced by two successive events: increased cell proliferation (tumor
or neoplasia) and the invasive capacity of these cells (metastasis). DNA
methylation is an epigenetic process which has been involved as an important
pathogenic factor of cancer. DNA methylation participates in the regulation of
gene expression, directly, by preventing the union of transcription factors,
and indirectly, by promoting the "closed" structure of the
chromatine. The objectives of this study were to identify hypermethyled chromosomal
regions through the use of restriction Alu I endonuclease, and to relate
cytogenetically these regions with tumor suppressive gene loci. Sixty
peripheral blood samples of females with breast cancer were analyzed.
Cell cultures were performed and cytogenetic spreads, previously digested with
Alu I enzyme, were stained with Giemsa. Chromosomal centromeric and not
centromeric regions were stained in 37% of cases. About 96% of stained
hypermethyled chromosomal regions (1q, 2q, 6q) were linked with methylated
genes associated with breast cancer. In addition, centromeric regions
in chromosomes 3, 4, 8, 13, 14, 15 and 17, usually unstained, were found
positive to digestion with Alu I enzime and Giemsa staining. We suggest the
importance of this technique for the global visualization of the genome which
can find methylated genes related to breast cancer, and thus lead to
a specific therapy, and therefore a better therapeutic response.
[Work disability criteria in breast cancer].
[Article in Spanish]
Vicente-Herrero MT, Terradillos García MJ, Ramírez Iñiguez de la Torre MV, Capdevila García LM, López-González AA.
Source
Medicina del Trabajo, Grupo
Correos-Valencia y Castellón, España. Grupo de Investigación en Medicina del
Trabajo (GIMT), España. teovicente@ono.com
Abstract
Breast cancer is one of the most frequent neoplasia in women, with an increasing
prevalence in Europe and also in Spain. Although the predominance over the male
sex is clear, we should not forget the cases where men are affected, even more
so when in this case the risks attached to the type of job become more
important. The importance of the indirect costs of this illness arises from:
the high prevalence in people of working age, long periods of work disability,
and permanent disability when the limitations are incompatible with the work
activity once all the options of job readjustment and return to work have been
exhausted. We will review the current criteria in order to establish some
orientating guidelines that can be useful in the daily practice for
Occupational Medicine professionals, General Practitioners and other specialists,
always in collaboration with the medical teams from the National Health Service
in charge of the evaluation of disabilities.
Copyright © 2012 Elsevier España, S.L. y SEMERGEN. All rights reserved.
[Co-expression of estrogen receptors and Her2/neu in breast cancer. Neoadjuvant chemotherapy sentinel lymph node
and hormonotherapy].
[Article in Spanish]
Source
Ginecologia y Obstetricia, Sección de
Patología Mamaria Hospital Universitario La Paz, Madrid, España.
dralopezcarpintero@yahoo.es
Abstract
Neoadjuvant chemotherapy is an interesting option in the therapy of some breast cancer
cases. Cases in which the timing for sentinel lymph node biopsy is
controversial. Co-expression of estrogen receptors and Her2/neu (c-erbB-2) in breast cancer
may imply hormone resistance, especially to tamoxifen. We present a clinic case
with co-expression of estrogen receptors and Her2/neu that was treated with
neoadjuvant chemotherapy and previous sentinel lymph node biopsy followed by
breasttumorectomy with axillar lymphadenectomy, radiotherapy and hormonotherapy
with letrozol, geserelina and trastuzumab. A good treatment response was found.
CONSTRUCTOR
DE MESH
("breast
neoplasms"[MeSH Terms] OR ("breast"[All Fields] AND
"neoplasms"[All Fields]) OR "breast neoplasms"[All Fields])
AND ("2003/07/10"[PDat] : "2013/07/06"[PDat] AND
"humans"[MeSH Terms] AND Spanish[lang] AND "female"[MeSH
Terms])
